Date of Award
M.S. in Pharmaceutical Science
Pharmaceutics and Drug Delivery
The total synthesis of polyhydroxylated flavones have proven to be challenging, due to the presence of more than one hydroxyl group. Direct cyclization was not successful in any of the attempts. However, by using a silyl protecting group, the cyclization was feasible. Other reactions like the Friedel-Crafts acylation and selective protection of phenols were also difficult.
Alkhodier, Reem, "Progress Toward the Synthesis of 3-Methoxyflavones as Potential Antioxidants, Neuroprotective Agents, and Trifluoromethylated 19F NMR Probes" (2019). Electronic Theses and Dissertations. 1574.
Available for download on Tuesday, September 22, 2020