Date of Award
Ph.D. in Pharmaceutical Sciences
Pharmaceutics and Drug Delivery
Michael A. Repka
S. Narasimha Murthy
Solid self-emulsifying drug delivery systems were developed instead of a conventional liquid system. Solid surfactants was chosen to emulsify lipids with different HLB properties. Type of surfactant, type of lipid, Lipid/surfactant L/S ratio, feed rate, screw speed and screw configuration, were the formulation and process parameters evaluated. Solid self-emulsifying drug delivery systems were successfully developed on the hot-melt extruder for the first time which is a continuous processing technology.
Thipsay, Priyanka, "Application of Quality by Design and Process Analytical Technology towards Hot-Melt Extrusion Processes" (2019). Electronic Theses and Dissertations. 1710.