Date of Award
Ph.D. in Pharmaceutical Sciences
Pharmaceutics and Drug Delivery
Michael A. Repka
New drug product development is a time consuming and costly process. One of the significant challenges is the poor aqueous solubility of many active pharmaceutical ingredients (APIs). Among those techniques, hot-melt extrusion(HME) is optimal for pharmaceutical solid dispersion development because of it free of using an organic solvent, easy scale up, and suitable for continuous processing with ensured optimal quality control.
Zhang, Jiaxiang, "Novel Application of Melt Extrusion and Additive Manufacturing on Developing Diverse Dosages" (2019). Electronic Theses and Dissertations. 1720.