Electronic Theses and Dissertations

Date of Award

1-1-2020

Document Type

Thesis

Degree Name

M.S. in Pharmaceutical Science

First Advisor

Michael A Repka

Second Advisor

Seongbong Jo

Third Advisor

Eman Ashour

School

University of Mississippi

Relational Format

dissertation/thesis

Abstract

The objective of this work was to develop taste-masked donut-shaped tablet formulations utilizing fused deposition modeling three-dimensional (3D) printing paired with hot-melt extrusion (HME) techniques. Caffeine citrate (CC) was used as the model drug for its bitter taste, and a three-point bend test was performed to assess the printability of filaments. The stiffness constant was calculated to represent the printability by fitting the breaking distances and stress data into Hooke's law. Formulation F6 and F7 filaments exhibited the desired hardness with a “k” value of 48.30 ± 3.52 g/mm3 and 45.47 ± 3.51 g/mm3, respectively, and were successfully printed. The donut-shaped tablets were 3D printed with 10%, 50%, and 100% infill densities. In vitro dissolution studies were performed in simulated salivary fluid (pH 6.8, artificial saliva) to evaluate the taste masking efficiency of the printed donuts. In the first minute, the concentrations of CC observed in the dissolution media from all the printed donuts were less than the bitter threshold of CC (0.25 mg/mL). Formulation F7, which contained Eudragit® E PO copolymer, demonstrated better taste masking efficiency than formulation F6. Furthermore, both formulations F6 and F7 demonstrated immediate drug release profiles in gastric medium (10% infill, >80% release within 1 h). Taste-masked CC formulations were successfully developed with donut shapes, which will enhance appeal in pediatric populations, and increase compliance and patient acceptance of the dosage form.

Available for download on Wednesday, August 31, 2022

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