Electronic Theses and Dissertations

Date of Award


Document Type


Degree Name

M.S. in Chemistry

First Advisor

Gregory S. Tschumper

Second Advisor

Walter Cleland

Third Advisor

Steven Davis


University of Mississippi

Relational Format



A recent computational analysis of the stabilizing intramolecular OH· · · O contact in 1,2-dialkyl-2,3-epoxycyclopentanol diastereomers has been extended to thiiriane, aziridine and phosphirane analogues. Density functional theory (DFT), second-order Møller-Plesset perturbation theory (MP2) and CCSD(T) coupled-cluster computations with simple methyl and ethyl substituents indicate that electronic energies of the cis isomers are lowered by roughly 3 to 4 kcal mol−1 when the OH group of these cyclopentanol systems forms an intramolecular contact with the O, S, N or P atom on the adjacent carbon. The results also suggest that S and P can participate in these stabilizing intramolecular interactions as effectively as O and N in constrained molecular environments. The stabilizing intramolecular OH· · · O, OH· · · S, OH· · · N and OH· · · P contacts also increase the covalent OH bond length and significantly decrease the OH stretching vibrational frequency in every system with shifts typically on the order of −41 cm−1 .

Included in

Chemistry Commons



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