Electronic Theses and Dissertations

Date of Award


Document Type


Degree Name

M.S. in Pharmaceutical Science

First Advisor

Michael A. Repka

Second Advisor

Walter G. Chambliss

Third Advisor

Eman Ashour

Relational Format



Albuterol sulfate is a short-acting selective Beta 2 Adrenergic agonist. It is used to treat and prevent bronchospasm associated with asthma, bronchitis, and other breathing disorders. It is known to show extensive first pass metabolism and it requires frequent dosing which makes it difficult for patients to comply. To avoid these problems, transdermal route of delivery of Salbutamol was explored. Traditional methods of preparation of transdermal drug delivery systems involve the use of solvents and have multiple processing steps. To avoid the usage of solvents and decrease the processing steps, HME Coupled FDM 3D printing can be used. Different polymers such as Polyox WSR N-80, Eudragit RSPO, Kollidon VA64, Parteck MXP Polyvinyl Alcohol, Kollidon 12PF, Polyox WSR 301, Affinisol 100 LV were used in combination with the drug to extrude filaments with 11mm Twin Screw Extruder and then printed into patches with Prusa ik MK3 FDM 3D printer. The patches were characterized for their thermal behaviour with Differential Scanning Calorimetry (DSC), for drug content, weight variation, thickness, folding endurance, patch burst strength with Texture Analyser (TA), moisture content, in-vitro drug release in Vertical Franz Diffusion cells. Patches with drug release of 99.8± 0.2 (mean± SD) at 24 hours were formulated.


Pharmaceutical sciences



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