Electronic Theses and Dissertations

Date of Award


Document Type


Degree Name

M.S. in Pharmaceutical Science

First Advisor

Seong Bong Jo

Second Advisor

Dr. Walter Chambliss

Third Advisor

Micheal A. Repka


University of Mississippi

Relational Format



Ferrocene is an orange solid with a camphor-like odor and is soluble in almost all organic solvents. It is known for its remarkable stability, as it is unaffected by air, water, and strong bases. Ferrocene derivatives also have great potential as anticancer and antimalarial agents, but their practical insolubility in water can limit their utility as a pharmaceutical active ingredient. In this study, the main aim is to form inclusion complexes between different ferrocene derivatives and hydroxypropyl-β-cyclodextrin (HP-β-CD) to enhance their water solubility and use the resulting complexes to test for cleavage of methylene blue ethanolamine (MB-EA) through Fenton's reaction for antimalarial activity. HP-β-CD is a large molecule with a hydrophobic cavity inside and a polar hydrophilic cavity outside that allows it to trap FC molecules and form water-soluble complexes. MB-EA is a dye molecule that is often used as a fluorescent probe. MB-EA also exhibits significant antimalarial properties. To confirm the formation of the inclusion complexes, various studies such as Differential scanning calorimetry (DSC), visual solubility testing with deionized water, and Nuclear magnetic resonance (NMR) were performed. Finally, the complex, along with MB-EA, was subjected to Fenton's reaction with H2O2 as the catalyst, and the release intensity of MB was analyzed using fluorometric analysis.

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