Electronic Theses and Dissertations


Nan JiFollow

Date of Award


Document Type


Degree Name

Ph.D. in Pharmaceutical Sciences

First Advisor

Michael A. Repka

Second Advisor

Chalet Tan

Third Advisor

Seongbong Jo


University of Mississippi

Relational Format



The immune system plays a crucial role in protecting the body from harmful pathogens and cancer cells and maintaining tissue homeostasis. Immunotherapy has shown significant potential in treating various diseases by harnessing the therapeutic potential of immune responses through the targeting of different immune cells, receptors, and signaling pathways. This dissertation investigated two immune modulators for their immune-enhancing potential.In the first chapter, the components of innate immunity are introduced. In the second chapter, Immulina, a commercially available extract of Arthrospira platensis enriched with Braun-type proteins, was studied for its immunostimulatory effect in mouse bone marrow-derived dendritic cells and macrophages. The results showed that Immulina stimulated the production of pro-inflammatory cytokines and chemokines at both mRNA and protein levels, indicating its potential as a potent immune activator. In the third chapter, a cationic liposome formulation was designed and optimized for the systemic delivery of a STING agonist, ADU-S100. The impact of key formulation factors on the loading efficiency, serum stability, and STING agonistic activity of ADU-S100 was investigated. Our findings demonstrated that the cationic liposomal formulation of ADU-S100 can potentiate STING activation and promotes dendritic cell maturation.

Available for download on Friday, September 13, 2024