Developing sequencing method of heparin/heparan sulfate oligosaccharides to explore potential drug candidates for central nervous system repair
Ph.D. in Pharmaceutical Sciences
Glycosaminoglycans (GAGs) are linear polysaccharides made up of repeating disaccharide units and are produced by virtually all mammalian cells on the cell surface. GAGs are involved in diverse biologicalprocesses, such as cell migration, cell specification, and cell adhesion. These processes require certain,but not fully clear,sulfate patternsor modifications of GAGs like N-and O-sulfation, N-acetylation, and epimerization of uronic acid residues. In biosynthesis, the modification of GAGs is incomplete and untemplated, which brings invaststructural heterogeneity.Thus,it is very challenging to understand the structure-function relationship of GAGs. Hp/HS are highly anionic GAGs which likely participate in enhanced CNS repair mechanisms and could be potential agents for the prevention and/or treatment of CNS damage. However, relatively little is known about Hp structure in CNS repair. This proposalwill help answer these unknown questions.
Liu, Hao, "Developing sequencing method of heparin/heparan sulfate oligosaccharides to explore potential drug candidates for central nervous system repair" (2019). Graduate Student Council Research Grants. 25.