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This study aims to examine the connection between international politics that characterized the outbreak of COVID-19, mainly between the United States of America and China and the devastating impact of the second wave outbreak on the Nigerian economy. At the initial stage of the pandemic on the Chinese mainland, the economy of China experienced a significant decline. The efficacy of China’s response to COVID-19 led to a fractional economic recovery during the pandemic. However, the internationalization of COVID-19 was greeted with a second wave in most advanced countries, such as the United States of America, Italy, and the United Kingdom, among others. The low level of preparedness and poor responses were comparably low in second-wave countries compared to China. It also examines the failure of the United States of America and China to develop a global health framework against COVID-19, as well as the Blame Game Politics that eventually played out. The politics of shifting blame between the United States of America and China, coupled with poor responses against COVID-19 in most Western countries, culminated in a devastating outbreak in low-income countries. Nigeria’s COVID-19 experience severely affected the critical sectors of the economy. However, this awkward situation has heightened Nigeria’s status as a major economic victim of the pandemic in Africa. The study utilized primary and secondary sources of data. The primary data were generated through the utility of Key Informant Interviews (KIIs), and the secondary data were generated from textbooks, journal articles, and web-based materials. The data generated were analyzed using the logic induction method and thematic analysis. The study recommends rejigging the Nigerian economic framework and improving revenues through an Agrobased economy.

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