Honors Theses

Date of Award

2017

Document Type

Undergraduate Thesis

Department

Chemistry and Biochemistry

First Advisor

Nathan Hammer

Relational Format

Dissertation/Thesis

Abstract

The isoenzymatic form of microsomal cytochrome P450, CYP2E1, is involved in the formation of oxygen free radicals, specifically hydroxyethyl ether. Chronic alcohol abuse has been found to induce larger levels of CYP2E1 in the liver, thus increasing production of these harmful free radicals. Generation of the hydroxyethyl ether oxygen free radicals occurs during the metabolism of ethanol in microsomes. The hydrogen-bonding interactions of hydroxyethyl ethers with water have yet to be analyzed, and information regarding the interactions with water can be applied directly to biological systems. Here, we employ Raman spectroscopy and computational chemistry to study hydroxyethyl ether complexes in micro-solvated networks of varying complexity.

Included in

Chemistry Commons

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