Honors Theses
Date of Award
Spring 5-9-2020
Document Type
Undergraduate Thesis
Department
Chemistry and Biochemistry
First Advisor
Nathan Hammer
Second Advisor
Gerald Rowland
Third Advisor
Gregory Tschumper
Relational Format
Dissertation/Thesis
Abstract
Covalent bonds are the strongest type of bonds holding molecules together. Based on the pattern of bonding of the molecule, the atoms associated with the bond will vibrate at a specific frequency. Utilizing vibrational spectroscopy, such as Raman spectroscopy, these unique vibrational frequencies can be used to detect the presence of analytes over a selected area. Furthermore, the intensities of the vibrational modes can be tracked to comparatively quantify the concentration of analytes at various locations. This is a method of great importance due to its ability to compare pharmaceutical tablets synthesized with different techniques. Here, the presence and concentration of ibuprofen in lipid matrix was observed. This was done in collaboration with a pharmaceutical lab with the hopes of producing a higher quality suppository tablet.
Recommended Citation
Pauly, Kyle Joseph, "Study of Pharmaceutical Tablets Using Raman Mapping" (2020). Honors Theses. 1441.
https://egrove.olemiss.edu/hon_thesis/1441
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Included in
Complex Mixtures Commons, Medicinal Chemistry and Pharmaceutics Commons, Pharmaceutical Preparations Commons, Physical Chemistry Commons