Date of Award
Chemistry and Biochemistry
Covalent bonds are the strongest type of bonds holding molecules together. Based on the pattern of bonding of the molecule, the atoms associated with the bond will vibrate at a specific frequency. Utilizing vibrational spectroscopy, such as Raman spectroscopy, these unique vibrational frequencies can be used to detect the presence of analytes over a selected area. Furthermore, the intensities of the vibrational modes can be tracked to comparatively quantify the concentration of analytes at various locations. This is a method of great importance due to its ability to compare pharmaceutical tablets synthesized with different techniques. Here, the presence and concentration of ibuprofen in lipid matrix was observed. This was done in collaboration with a pharmaceutical lab with the hopes of producing a higher quality suppository tablet.
Pauly, Kyle Joseph, "Study of Pharmaceutical Tablets Using Raman Mapping" (2020). Honors Theses. 1441.
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