Honors Theses

Date of Award

Spring 5-9-2020

Document Type

Undergraduate Thesis

Department

Biology

First Advisor

Tossi Ikuta

Relational Format

Dissertation/Thesis

Abstract

This study was conducted to investigate whether the influence of arthritis has an effect on the cerebral white matter. The project was performed at the South Oxford Campus, where diffusion tensor imaging (DTI) data was obtained from the Nathan Kline Institute-Rockland Sample (NKI- RS). Image processing was conducted using Functional Magnetic Resonance Imaging of Brain Software Library in which we obtained raw data to formulate Apparent Diffusion Coefficient (ADC), Axial Diffusivity (AD), Radial Diffusivity (RD), and Fractional Anisotropy. A one way Analysis of Covariance (ANCOVA) was performed to determine the significant difference between the history of arthritis on each of the DTI measures only controlling age (30 years or older) and sex (male and female). There was a significant effect of history of arthritis on ADC, AD, and RD when sex and age was controlled based on the p value significance. It is suggested that the history of arthritis, the effect of inflammation, and possibly medication for arthritis may increase white matter integrity of the cerebrum.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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