Date of Award
Pharmaceutics and Drug Delivery
Methylene blue (MB) has many uses within both microbiology and pharmacology. MB can treat disorders such as methemoglobinemia, malaria, Alzheimer’s disease, and certain forms of cancer. MB is also useful for molecular imaging due to its off-on fluorescent capabilities. MB derivatives with a urea bond at the 10-N position have been cleavable by triggers such as light. However, I was interested in sensitivity to reactive oxygen species (ROS). In this study, I wanted to determine if the MB derivative MB-EA exhibited sensitivity to ROS. MB-EA was exposed to varying concentrations of hydrogen peroxide and MB release was measured. I concluded that MB-EA is increasingly sensitive to increasing concentrations of hydrogen peroxide, and exhibits sensitivity to ROS. This could allow for new MB therapeutics to be administered in diseases that produce ROS.
Weeks, Matthew, "Fluorometric Characterization of a Methylene Blue Derivative Sensitive to Reactive Oxygen Species (ROS)" (2020). Honors Theses. 1533.
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