Honors Theses

Date of Award

Spring 5-7-2022

Document Type

Undergraduate Thesis


Chemistry and Biochemistry

First Advisor

Nathan Hammer

Relational Format



Gelatin nanoparticles have been known to be used as a drug transporter to target sick tissues like those of cancer. Gelatin nanoparticles have long been engineered by one-step and two-step desolvation processes. Yet, manufacturing gelatin nanoparticles of reproducible size has not been accomplished successfully. This research will look at how the starting processing steps such as gelatin solution pH adjustment and incubation times influenced the size of gelatin nanoparticles. Gelatin solution pH incubation times between 0 and 24 hours showed an increase in gelatin nanoparticle size in those manufactured by one-step desolvation. Two-step desolvation engineered gelatin nanoparticles showed a smaller size of gelatin nanoparticles than those engineered by one-step desolvation. The findings from this paper demonstrate the role that gelatin solution pH and incubation time have on size and size distribution of gelatin nanoparticles. Two-step desolvation showed better physical stability in terms of size and size distribution when compared to one-step desolvation.

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