Honors Theses
Date of Award
Spring 5-6-2020
Document Type
Undergraduate Thesis
Department
Chemistry and Biochemistry
First Advisor
Nathan I. Hammer
Second Advisor
Robert J. Doerksen
Third Advisor
Murrell Godfrey
Relational Format
Dissertation/Thesis
Abstract
Cannabis and products containing its cannabinoids have grown rapidly in acceptance and use in recent years with legalization of cannabis in many countries and US states. Cannabidiol and Delta-9-Tetrahydrocannabinol are two primary cannabinoids in Cannabis that have been shown to produce analgesic effects along with many other positive side effects for the user. These two cannabinoids interact with receptors in the Central and Peripheral Nervous Systems. No spectroscopic study to our knowledge has been performed to analyze the hydrogen bonding effects of interactions between these two cannabinoids and solvents. Here, we employ theoretical Raman spectra through computational methods to study hydrogen bonding between cannabinoids and water, ethanol and methanol. Additionally, computational chemistry was utilized in an effort to identify the lowest energy conformations of Delta-9-THC and CBD in the presence of solvents. Experimental Raman spectroscopy was also applied in an effort to acquire the highest resolution Raman spectra ever recorded for CBD and Delta-9-THC to date. Due to the COVID-19 pandemic, experimental work was limited and will likely be completed in future work.
Recommended Citation
Sigworth, Kalee, "Raman Spectroscopy Study of Delta-9-Tetrahydrocannabinol and Cannabidiol and their Hydrogen-Bonding Activities" (2020). Honors Theses. 1411.
https://egrove.olemiss.edu/hon_thesis/1411
Accessibility Status
Searchable text
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.