Honors Theses
Date of Award
Spring 5-8-2021
Document Type
Undergraduate Thesis
Department
Chemical Engineering
First Advisor
Daniell Mattern
Second Advisor
Nikki Reinemann
Third Advisor
Gerald Rowland
Relational Format
Dissertation/Thesis
Abstract
The process of developing a working base case procedure for a novel one-pot-two-step synthesis of primary amines from Grignard reagents, nitriles, sodium metal or alkali metal loaded silica gel, and alcohol is described. Initial steps towards applying the process broadly are detailed. The process has the potential to be an affordable, convenient, safer, greener, and more accessible alternative to exiting methods of accomplishing the same transformation. The reaction scheme has been proven to provide yields and purity comparable to existing methods for certain pairs of substrates; however, its utility as a general-purpose method for transforming arbitrary pairs of Grignard reagent and nitrile to their corresponding branched primary amine has yet to be demonstrated. Recommendations for further investigation are given
Recommended Citation
Peltan, Joshua, "One-Pot Synthesis of Disubstituted Primary Amines from Nitriles Via Grignard Addition and Metal-Alcohol Reduction" (2021). Honors Theses. 1853.
https://egrove.olemiss.edu/hon_thesis/1853
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This work is licensed under a Creative Commons Attribution 4.0 International License.