LC-MS Identification of Serum Proteins Adsorbed onto Ionic Liquid-Coated Nanoparticles

Author

Anh M. HoangFollow

Date of Award

Spring 5-8-2022

Document Type

Undergraduate Thesis

Department

Chemistry and Biochemistry

First Advisor

Eden Tanner

Relational Format

Dissertation/Thesis

Abstract

Nanocarriers are promising candidates for drug delivery due to their size and tunable surface characteristics. However, when they are intravenously injected, few particles make it to their designated location. This is because upon entering the bloodstream, the serum in the blood, which is rich with a diversity of proteins, adsorbs onto the particles’ surfaces forming a protein corona. Many of the attached proteins trigger the mobile immune system and are removed by macrophages, and many particles are then filtered out by the liver and kidneys. Ionic Liquids (ILs), which consist of asymmetric, bulky components that are liquid

Recommended Citation

Hoang, Anh M., "LC-MS Identification of Serum Proteins Adsorbed onto Ionic Liquid-Coated Nanoparticles" (2022). Honors Theses. 2589.
https://egrove.olemiss.edu/hon_thesis/2589

Accessibility Status

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