Honors Theses

Date of Award

Spring 5-9-2020

Document Type

Undergraduate Thesis


Biomolecular Sciences

First Advisor

David A. Colby

Second Advisor

John Rimoldi

Third Advisor

Jason Paris

Relational Format



GABA is a neurotransmitter that inhibits the excitation of neurons. Targeting this specific receptor has the potential to inhibit the central nervous system and possibly treat addiction, anxiety, or mood disorders. Previous research has shown that fluorinated ketones can have valuable applications in the medicinal chemistry of addiction. Some fluorinated ketones have shown activity at the GABA receptor. The main goal of this project was to synthesize aromatic fluorinated ketones for biological evaluation at the GABAB receptor. Another goal was to compare both the monofluorinated and difluorinated analogues synthesized in order to quantify differences in activity from fluorination state. New fluorinated agonists for the GABAB receptor present potential for pharmacological development because of the distinct structure in comparison to other GABA analogues. These compounds may assist in overcoming some of the current limitations in drug discovery at the GABAB receptor and are to be submitted for biological evaluation.



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