Honors Theses

Date of Award

Spring 5-9-2020

Document Type

Undergraduate Thesis



First Advisor

Bradley Jones

Second Advisor

Sarah Liljegren

Third Advisor

Mika Jekabsons

Relational Format



Apoptosis, also known as programmed cell death, is a cellular process used for development or for when cells undergo injury or stress. The Bcl2 family of proteins includes both pro-apoptotic and anti-apoptotic proteins that control the intrinsic pathway of apoptosis. Understanding the mechanisms and influence these proteins have on apoptosis is an important area of research focused on in Dr. Jones’s lab. Evidence shows a homology amongst the Bcl2 family of proteins at the BH3 domain. Dr. Jekabsons' lab has found a potential homology amongst VDAC 1-3 and the Bcl2 family at the BH3 domain.

Specifically, our lab is using Drosophila melanogaster to test the interaction between VDACs and Bax by mutating the Drosophila’s VDAC. We are interested in discovering if mutation of this domain causes a phenotypic change in the Drosophila melanogaster, and if the change is harmful or beneficial. We constructed transgenic plasmids using a pUBI-ATTB plasmid as a vector and mouse VDAC cDNA as our gene of interest. We hypothesize that Bax and VDAC interact to prevent the premature assembly of Bax pores in the mitochondrial membrane.

Accessibility Status

Searchable text

Creative Commons License

Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.