Honors Theses

Date of Award

Spring 5-1-2021

Document Type

Undergraduate Thesis



First Advisor

Thomas Werfel

Second Advisor

Glenn Walker

Third Advisor

Paul Boudreau

Relational Format



By applying cardiovascular drugs, which already have been proven effective and safe, to other diseases we can speed the drug discovery process, specifically to translate them into treatments for platelet-mediated metastasis. Each cardiovascular drug within antiplatelet drugs, targets one of the four following pathways: COX-1, thromboxane, P2Y12, or thrombin. There has been varying levels of success with treating adenocarcinomas like breast and colorectal cancer. Continued success in treatment could be the result of pharmacogenetics and further evaluation of dosage levels. By isolating mutation rates in various adenocarcinomas there is the possibility of a targeted treatment based on the mutated gene.

Accessibility Status

Searchable text



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.