Date of Award
By applying cardiovascular drugs, which already have been proven effective and safe, to other diseases we can speed the drug discovery process, specifically to translate them into treatments for platelet-mediated metastasis. Each cardiovascular drug within antiplatelet drugs, targets one of the four following pathways: COX-1, thromboxane, P2Y12, or thrombin. There has been varying levels of success with treating adenocarcinomas like breast and colorectal cancer. Continued success in treatment could be the result of pharmacogenetics and further evaluation of dosage levels. By isolating mutation rates in various adenocarcinomas there is the possibility of a targeted treatment based on the mutated gene.
Chambers, Brianna, "Repurposing Antiplatelet Drugs to Treat Platelet Mediated Metastasis" (2021). Honors Theses. 1666.