Honors Theses

Date of Award

Spring 4-30-2020

Document Type

Undergraduate Thesis


Biomedical Engineering

First Advisor

Troy Drewry

Second Advisor

Glenn Walker

Third Advisor

Lloyd Wade

Relational Format



Orthopedic infection in the United States is one of the most common and severe health risks faced by trauma patients. The most prevalent infection is orthopedic and trauma device-related infection (ORDI) and often occurs in long bones at the fracture site. The purpose of this paper is to explore this infection, its causes, and solutions currently on the market while providing novel solutions to the problem. The designs proposed will be evaluated for their effectiveness and value, while attempting to keep costs low for all stakeholders. The feasibility of patenting these ideas will also be considered, as will the testing procedures, and regulatory pathways. Literature review reveals that the best methods are targeted drug delivery and controlled release of antibiotics, however, it is imperative that the antibiotic release does not compromise the strength of the implant. In using the proposed devices, orthopedic surgeons will see fewer infections and will not need to perform repeat surgeries as often. All in all, small reductions in these infections could represent massive savings for doctors, hospitals, and patients alike.



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