Honors Theses

Date of Award

Spring 5-2-2021

Document Type

Undergraduate Thesis


Communication Sciences and Disorders

First Advisor

Toshikazu Ikuta

Second Advisor

Anne Williams

Third Advisor

Alberto Jose Del Arco Gonzalez

Relational Format



Objectives: The corpus callosum of the brain is an important and complex structure that allows communication between the two cerebral hemispheres. In the absence of knowledge about the relationship between the corpus callosum and the auditory cortices, this study aimed to investigate how the structure changes. Specifically, we explored the age associated changes of interhemispheric connectivity between left and right cortices through the corpus callosum.Methods: Using Diffusion Tensor Imaging (DTI) data from enhanced Nathan Kline Institute- Rockland Sample (NKI-RS), we isolated the auditory corpus callosum, or the section of the corpus callosum that transfers auditory information, in each individual subject (N=466) using probabilistic tractography. As a measure of the white matter microstructure integrity, the mean fractional anisotropy (FA) of the whole auditory corpus callosum was examined and tested for an association with age.

Results: A significant association between age and the auditory corpus callosum was found. Age was associated with an increase in the integrity of the auditory corpus callosum, adjusted for sex.Discussion: The current study does not prove a causal relationship between age and auditory corpus callosum integrity, but it is the first evidence of a relationship. This information provides new evidence on the hearing and neurological systems of the body, and how this relationship impacts our daily lives and audiological practice.

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