Date of Award
Communication Sciences and Disorders
Alberto Del Arco
This study sought to explore the relationship between Parkinson’s Disease (PD), the amygdala, and the plethora of non-motor symptoms that plague individuals with PD. Previous research gave insights about the amygdala’s function as the emotional center of the brain, its role in depression, and its participation in the non-motor symptoms of PD. The research proved to still be inconclusive on its own because of a variety of limitations. The methods of this study consist of the analysis of Functional Magnetic Resonance Imaging (fMRI) scans from 93 individuals with PD and 18 individuals without PD while in a resting state. The analysis showed that the amygdalae experienced decreased functional connectivity (FC) to the right posterior areas of the superior frontal gyrus (SFG). Because this depletion of FC is similar to the neurological effects of Major Depression Disorder (MDD), it is suggested that depression in PD is caused by the amygdala’s inability to communicate effectively with the right posterior SFG.
Gammill, Callie Claire, "Parkinson's Disease, the Amygdala, and Non-motor Symptoms" (2021). Honors Theses. 1879.