The Role of Cannabinoid Receptor 2 in Zebrafish Toxicities Following Developmental Exposure to THC or CBD
Date of Award
As the laws concerning the regulation of Cannabis Sativa change across the globe, maternal use of cannabinoid-containing products during pregnancy is a greater concern than ever before. Little research has been conducted on the consequences of maternal use and developmental exposure to ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD. In this study, larval zebrafish (Danio rerio) were used to measure CBD and THC-mediated adverse outcomes including effects on larval length, eye area, and behavior in the cnr+/+ and cnr2-/- zebrafish strains where we discovered that cannabinoid exposure results in a decrease in each of these endpoints. Adult zebrafish were used to further examine the effects that receptor knockout has on behavior which also resulted in decreased behavior. This study found that developmental exposure to THC and CBD did result in toxicities, however, toxicities were lessened in zebrafish that lacked cannabinoid receptor 2 suggesting that this receptor has an important role in modulating the effects of cannabinoid exposure and is possibly involved in protective pathways.
Watts, Haley, "The Role of Cannabinoid Receptor 2 in Zebrafish Toxicities Following Developmental Exposure to THC or CBD" (2021). Honors Theses. 1889.
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