Th1, Th2, and TH17 Inflammatory Pathways Predict Cardiometabolic Protein Expression in Serum of Covid-19 Patients
Date of Award
A predominant source of complications in SARS-CoV-2 patients arises from severe systemic inflammation contributed to by Helper T-cell associated cytokines, potentially leading to tissue damage and organ failure. The high inflammatory burden of this viral infection often results in cardiovascular comorbidities. A better understanding of the interaction between the cytokine storm and cardiovascular proteins might inform medical decisions and therapeutic approaches. We hypothesized that all major helper T-cell inflammatory pathways (Helper T 1, Helper T 2 and Helper T 17) synergistically contribute to cardiometabolic pathways in serum of COVID-19 patients, and that both of these factors correlate to COVID-19 severity. We found that Helper T 1, Helper T 2, and Helper T 17 cytokines and chemokines are able to predict expression of 186 cardiometabolic proteins profiled by OLINK proteomics.
Michels, James Richard, "Th1, Th2, and TH17 Inflammatory Pathways Predict Cardiometabolic Protein Expression in Serum of Covid-19 Patients" (2022). Honors Theses. 2544.
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