Honors Theses

Date of Award

Spring 5-7-2022

Document Type

Undergraduate Thesis


Biomedical Engineering

First Advisor

Ana Pavel

Second Advisor

Glenn Walker

Third Advisor

Nikki Reinemann

Relational Format



A predominant source of complications in SARS-CoV-2 patients arises from severe systemic inflammation contributed to by Helper T-cell associated cytokines, potentially leading to tissue damage and organ failure. The high inflammatory burden of this viral infection often results in cardiovascular comorbidities. A better understanding of the interaction between the cytokine storm and cardiovascular proteins might inform medical decisions and therapeutic approaches. We hypothesized that all major helper T-cell inflammatory pathways (Helper T 1, Helper T 2 and Helper T 17) synergistically contribute to cardiometabolic pathways in serum of COVID-19 patients, and that both of these factors correlate to COVID-19 severity. We found that Helper T 1, Helper T 2, and Helper T 17 cytokines and chemokines are able to predict expression of 186 cardiometabolic proteins profiled by OLINK proteomics.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.



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