Th1, Th2, and TH17 Inflammatory Pathways Predict Cardiometabolic Protein Expression in Serum of Covid-19 Patients

Author

James Richard MichelsFollow

Date of Award

Spring 5-7-2022

Document Type

Undergraduate Thesis

Department

Biomedical Engineering

First Advisor

Ana Pavel

Second Advisor

Glenn Walker

Third Advisor

Nikki Reinemann

Relational Format

Dissertation/Thesis

Abstract

A predominant source of complications in SARS-CoV-2 patients arises from severe systemic inflammation contributed to by Helper T-cell associated cytokines, potentially leading to tissue damage and organ failure. The high inflammatory burden of this viral infection often results in cardiovascular comorbidities. A better understanding of the interaction between the cytokine storm and cardiovascular proteins might inform medical decisions and therapeutic approaches. We hypothesized that all major helper T-cell inflammatory pathways (Helper T 1, Helper T 2 and Helper T 17) synergistically contribute to cardiometabolic pathways in serum of COVID-19 patients, and that both of these factors correlate to COVID-19 severity. We found that Helper T 1, Helper T 2, and Helper T 17 cytokines and chemokines are able to predict expression of 186 cardiometabolic proteins profiled by OLINK proteomics.

Recommended Citation

Michels, James Richard, "Th1, Th2, and TH17 Inflammatory Pathways Predict Cardiometabolic Protein Expression in Serum of Covid-19 Patients" (2022). Honors Theses. 2544.
https://egrove.olemiss.edu/hon_thesis/2544

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This work is licensed under a Creative Commons Attribution 4.0 International License.