Date of Award
School of Pharmacy
Advanced glycation end products (AGEs) are protein, lipid, or nucleotide molecules that have been combined with sugars through nonenzymatic, irreversible glycation and oxidation reactions. Their accumulation in the body has been associated with the natural aging process and a wide range of pathologies, including chronic inflammation, sustained oxidative stress, diabetes, neurodegenerative diseases, atherosclerosis, and cancer. Their interaction with the receptor for advanced glycation end products (RAGE) has been linked to several proinflammatory signaling pathways associated with neurotoxicity and vascular lesions. While some research has been done on the possible health benefits of RAGE inhibition to extend lifespan, our study hopes to further explain the role of AGE accumulation and AGE/RAGE signaling in directly contributing to the aging process in the hopes of extending healthspan.
Ashmore, Brandon, "All the RAGE: Assessing the AGE/RAGE Signaling Pathway’s Effects on Healthspan and the Physiological Processes of Aging" (2023). Honors Theses. 2975.
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