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Computational studies to determine the binding site of ORG27569, a negative allosteric modulator, within the cannabinoid receptor 1 (CB1) reveal an intracellular binding domain as the most favorable binding site for ORG27569.
cannabinoid receptor, CB1, allosteric modulation, ORG27569, molecular dynamic simulations
Natural Products Chemistry and Pharmacognosy | Pharmacy and Pharmaceutical Sciences
Aderibigbe, AyoOluwa O.; Pandey, Pankaj; and Doerksen, Robert J., "Determining the binding site of ORG27569 within the CB1 receptor" (2019). Faculty and Student Poster Sessions. 1.