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Description
Irvingia gabonensis (Aubry-Lecomte ex O’Rorke) Baill (Irvingiaceae), commonly known as African mango is a multipurpose tree providing food, medicine, and timber. Native to West and Central Africa, it is grown in various tropical and subtropical regions of the world. The seed kernel is of economic importance due to its popularity in local and international trade. It has now become a popular herbal weight-loss supplement, particularly in the United States. Seventeen compounds of diverse classes including four flavonoid glycosides, five ellagic acid derivatives, and eight other metabolites were isolated from the methanolic extract of the defatted seed kernel of Irvingia gabonensis. Among the isolates, quercetin 3-O-methyl-4′-[α-L-rhamnopyranosyl-(1→3)]-O-α-L-rhamnopyranoside (1) and 3,3′-di-O-methyl-4′-O-α-L-rhamnopyranosylellagic acid 4-sulfate ester (2) were found to be previously undescribed. Structure elucidation was mainly based on 1D- and 2D-NMR and HRESIMS data. The isolated compounds could be used as markers for authentication and standardization of Irvingia gabonensis commercial preparations.
Publication Date
2-21-2024
Relational Format
poster
Recommended Citation
Zulfiqar, Fazila; Chittiboyina, Amar; Ali, Zulfiqar; Viljoen, Alvaro M.; and Khan, Ikhlas A., "Ellagic acid and Flavonoid-based Metabolites from the Seed Kernel of Irvingia gabonensis" (2024). Annual Poster Session 2023-2024. 13.
https://egrove.olemiss.edu/pharm_annual_posters_2024/13