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Adherence to Janus Kinase Inhibitors Among Older Adults with Rheumatoid Arthritis Initiating New Treatment
Shadi Bazzazzadehgan, Arman Arabshomali, Yinan Huang, and Kaustuv Bhattacharya
Janus Kinase Inhibitors (JAKIs) are a recent advancement in Rheumatoid Arthritis (RA) treatment, offering an effective oral therapy option. However, adherence to JAKIs in RA patients is suboptimal compared to injectable options. Additionally, there is limited research on adherence to JAKIs among older adults in the United States. The study in question focused on examining JAKIs adherence in older RA patients enrolled in Medicare and identifying factors contributing to poor adherence.
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Trends and Regional Variation in New Opioid Prescriptions and Long-Term Prescription Opioid Use among Older Adults in the United States, 2012-2020
Shadi Bazzazzadehgan, Kaustuv Bhattacharya, Sujith Ramachandran, John P. Bentley, Ike Eriator, and Yi Yang
Corresponding with CDC’s Guideline for Prescribing Opioids for Chronic Pain in 2016, policies and procedures enacted by private and public institutions, prescriptions for opioid medications have been declining. However, the trends of opioid use change among older adults remains poorly understood, probably because older people are not at the center stage of the national opioid crisis. This study aimed to provide updates on utilization and trends in new opioid prescriptions and new long-term opioid episode among older adults enrolled in Medicare.
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Systematic Review of Real-World Data: Assessing Cancer, Major Adverse Cardiovascular Events, Venous Thromboembolism, Infection, and Mortality Risk Associated With JAK Inhibitors in Rheumatoid Arthritis Patients in the United States
Shadi Bazzazzadehgan, Chandler Gandy, Sebastian Bruera, and Yinan Huang
Janus kinase inhibitors (JAKi) are novel oral therapy option for rheumatoid arthritis (RA) patients. However, data from the randomized controlled trials (RCTs) found an increased risk of cancer, serious cardiovascular events, blood clots, and death with JAKi. Patients enrolled in RCTs do not represent general patient population in real world. It is essential to complete the body of evidence with real-world data (RWD).
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Knowledge and Perceptions of Pharmacogenomics among Mississippi Pharmacists
Nicholas Dean and Erin Holmes
Pharmacogenomics (PGx) is a new and emerging area of study in the field of precision therapy, which aims to tailor the treatment to the individual, in this case medications (NIGMS). The purpose of this study is to determine Mississippi pharmacists’ level of objective/subjective PGx knowledge; attitudes towards PGx testing, education, and ethics; and readiness to use and previous usage of PGx in practice.
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Chemistry and DMPK Core Facility
Rama S. Gadepalli and John M. Rimoldi
Medicinal chemistry is one of the vital components of the iterative cycle of drug discovery. This component is embedded in hit-to-lead and lead optimization stages. Twelve years of collective experiences and services provided by this Chemistry DMPK Core support the view that a majority of investigators are faced with two significant hurdles in advancing their research programs: compound acquisition and early-stage compound evaluation. This Core has bridged the gap by providing investigators with consultation, training, and services in medicinal chemistry, drug metabolism, and analysis, helping alleviate the bottleneck associated with compound acquisition and evaluation
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Pharmacy Residency Research: Flipped Model
Rebecca Heath, Tressa McMorris, and Adam Pate
The University of Mississippi School of Pharmacy has two American Society of Health-System Pharmacists (ASHP) accredited residency programs: Post-graduate year 1 (PGY1) Community-Based Pharmacy Residency, Post-Graduate year 2 (PGY2) Ambulatory Care Residency. All five residents participate in a longitudinal, year-long research experience. They have two research advisors who provide overarching research guidance and an individual research advisor who provides guidance specific to their project
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Evaluating Integrated Introductory Pharmacy Practice Experience
Anastasia Jenkins, Karmen Garey, and Natalie Montgomery
Introductory Pharmacy Practice Experiences (IPPEs) are a required component of the professional curriculum. During the IPPE, students spend time at a clinical site where they see all components of patient care and the medication use process. The purpose of the IPPE is to blend students' knowledge from the classroom into patient care. IPPE structure varies, with schools adopting either an integrative (experiential hours acquired longitudinally) or immersion (experiential hours acquired consecutively) experience. The University of Mississippi School of Pharmacy (UMSOP) utilizes both formats (integrative and immersion) during the P1-P3 years.
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Formulation Development and Characterization of Dual Drug Loaded Hot-Melt Extruded Inserts for Better Ocular Therapeutic Outcomes: Sulfacetamide/Prednisolone
Indrajeet Karnik, Ahmed Adel Ali Youssef, Poorva Joshi, Siva Ram Munnangi, Sagar Narala, Corinne Varner, Sateesh Vemula, Soumyajit Majumdar, and Michael Repka
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Analysis of Crocetins and Safranal variations in Saffron (Crocus sativus) Stigma Samples and Dietary Supplements using HPLC/UHPLC-PDA-MS: Chemical Profiling and Chemometric Analysis using LC-QToF
Kumar Katragunta, Bharathi Avula, Ya-Hong Wang, Roy Upton, and Ikhlas A. Khan
Saffron, the most expensive spice in the world, is comprised of dried and dark red stigma of Crocus sativus L. flowers of the Iridaceae family. It is mainly used as a spice for imparting color, fragrance, and flavor to food, but its medicinal and dyeing properties are also well known. In the United States, saffron products are used as dietary supplements for mood elevation, relaxation, weight loss, and to increase metabolism. This paper describes two analytical methods for the determination of crocetin esters, picrocrocin, and safranal in saffron samples and dietary supplements for inclusion in a monograph under development by the American Herbal Pharmacopoeia. Method validation showed satisfactory results in linearity, precision and recovery. The content of picrocrocin, safranal and crocetin esters ranged from 0.6-10.2%, 0.02-0.22%, and 2.8- 25.6%, respectively for thirty-seven stigma samples. Twenty-nine dietary supplements were analyzed. No saffron compounds were found in 16 (55%) of these products. Flower of Carthamus tinctorius and fruit of Gardenia jasminoides were the main adulterants detected in dietary supplements. Summarily, 60 compounds, including five standards were tentatively identified from saffron stigma, style, and petal samples using high resolution mass spectrometry. Principle component analysis was used to discriminate between saffron stigma samples and dietary supplements. The results indicated that commercial products are of variable quality and that this analytical method is suitable for quality assessment of a variety of both raw material and finished dietary supplements.
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University of Mississippi Botanical Dietary Supplements Research Center
Ikhlas A. Khan, Nirmal D. Pugh, Amar Chittiboyina, Chalet Tan, Gailen D. Marshall, M. Khalid Ashfaq, and Shabana Khan
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Community Pharmacy Enhanced Services Network (CPESN) Mississippi Research Opportunities
Lindsey Miller, Joseph A. Dikun, and Erin L. Pearson
CPESN, or Community Pharmacy Enhanced Services Network, is a clinically integrated network that allows pharmacies to aggregate and pursue contracts from payers as a group rather than as individual entities. Being a part of a clinically integrated network allows member pharmacies to engage with one another to improve the quality of patient care and offer value to payers through enhanced services while lowering pharmacy costs. CPESN USA consists of over 50 local networks, including CPESN Mississippi. Currently, there are 61 pharmacies that have joined CPESN Mississippi and have met the Minimum Standards to offer Comprehensive Medication Reviews, Medication Synchronization Programs, Immunizations, Medication Reconciliation, Personal Medication Record, and Face-to-Face Patient Access.
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Computational Chemistry and Bioinformatics Research CORE (CCBRC)
Sushil K. Mishra, Priyanka Samantha, Mohamed E. Jahan, and Robert J. Doerksen
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Utilizing 3D Printed Lung Phantoms for Patient-Specific History Storage, Follow-Up, and Lesion Visualization in CT Scanning
Ahmed Mo Mortada, Jaidev Chakka, Yu Zhang, Ayman Mokhtar Said, Mona Hussein Ibrahim, Tarek Mohsen, and Mohammed Maniruzzaman
This research proposes an innovative solution using 3D printing technology to create lung tissue phantoms for improved COVID-19 visualization and diagnosis. A dataset of 100 CT scans, including 60 COVID-19 positive cases, was utilized for lung tissue segmentation via 3D Slicer software.
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Opioid Tapering and Its Associations with Risk of Opioid Use Disorder and Mortality Among Older Adults
Yi Yang, Sujith Ramachandran, Kaustuv Bhattacharya, Shishir Maharjan, Ike Eriator, Shadi Bazzazzadehgan, and John P. Bentley
Corresponding with CDC’s Guideline for Prescribing Opioids for Chronic Pain in 2016 and policies and procedures enacted by payers, quality organizations, and state agencies, prescriptions for opioid medications have witnessed a sharp decreasing trend with increases in opioid dose tapering and discontinuation. But opioid-related mortality has not shown a parallel decline. Several observational studies have explored the potential adverse effects of opioid dose tapering and discontinuation, with a growing focus on the rate of dose tapering. We hypothesized that many of the negative consequences of opioid tapering may be associated with the rate of opioid tapering or discontinuation.
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Ellagic acid and Flavonoid-based Metabolites from the Seed Kernel of Irvingia gabonensis
Fazila Zulfiqar, Amar Chittiboyina, Zulfiqar Ali, Alvaro M. Viljoen, and Ikhlas A. Khan
Irvingia gabonensis (Aubry-Lecomte ex O’Rorke) Baill (Irvingiaceae), commonly known as African mango is a multipurpose tree providing food, medicine, and timber. Native to West and Central Africa, it is grown in various tropical and subtropical regions of the world. The seed kernel is of economic importance due to its popularity in local and international trade. It has now become a popular herbal weight-loss supplement, particularly in the United States. Seventeen compounds of diverse classes including four flavonoid glycosides, five ellagic acid derivatives, and eight other metabolites were isolated from the methanolic extract of the defatted seed kernel of Irvingia gabonensis. Among the isolates, quercetin 3-O-methyl-4′-[α-L-rhamnopyranosyl-(1→3)]-O-α-L-rhamnopyranoside (1) and 3,3′-di-O-methyl-4′-O-α-L-rhamnopyranosylellagic acid 4-sulfate ester (2) were found to be previously undescribed. Structure elucidation was mainly based on 1D- and 2D-NMR and HRESIMS data. The isolated compounds could be used as markers for authentication and standardization of Irvingia gabonensis commercial preparations.
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