Pituitary Gland Functional Connectivity and BMI

Authors

Paige Rucker, University of Mississippi Medical Center
Toshikazu Ikuta, University of MississippiFollow

Document Type

Article

Publication Date

2019

Abstract

The pituitary gland (PG) influences body weight through hormonal releases; however, the relation between body weight and PG’s co-activities with other brain regions remains unclear. Here, we aimed to identify (1) the functional connectivity of the PG and (2) PG functional connectivity associated with body mass index by examining resting state functional magnetic imaging (rsfMRI) data. Using enhanced Nathan Kline Institute-Rockland Sample, PG functional connectivity of 494 individuals was analyzed to assess in voxel-wise fashion. A negative association was found between BMI and PG functional connectivity with the orbitofrontal cortex, hippocampus, putamen and temporal lobe. Our results show PG dysconnectivity to these regions is associated with higher BMI and implicate that the connectivity between these dopaminergic regions and PG is associated with body weight maintenance through feeding behavior and growth.

Relational Format

Journal Article

Comments

The Article Processing Charge for this article was partially funded by the UM Libraries Open Access Fund.

Recommended Citation

Rucker, P., & Ikuta, T. (2019). Pituitary Gland Functional Connectivity and BMI. Frontiers in Neuroscience, 13. doi:10.3389/fnins.2019.00120

DOI

10.3389/fnins.2019.00120

Accessibility Status

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