Faculty and Student Publications
Document Type
Article
Publication Date
6-3-2017
Abstract
Background
Evidence for olfactory dysfunction in schizophrenia has been firmly established. However, in the typical understanding of schizophrenia, olfaction is not recognized to contribute to or interact with the illness. Despite the solid presence of olfactory dysfunction in schizophrenia, its relation to the rest of the illness remains largely unclear. Here, we aimed to examine functional connectivity of the olfactory bulb, olfactory tract, and piriform cortices and isolate the network that would account for the altered olfaction in schizophrenia.
Methods
We examined the functional connectivity of these specific olfactory regions in order to isolate other brain regions associated with olfactory processing in schizophrenia. Using the resting state functional MRI data from the Center for Biomedical Research Excellence in Brain Function and Mental Illness, we compared 84 patients of schizophrenia and 90 individuals without schizophrenia.
Results
The schizophrenia group showed disconnectivity between the anterior piriform cortex and the nucleus accumbens, between the posterior piriform cortex and the middle frontal gyrus, and between the olfactory tract and the visual cortices.
Conclusions
The current results suggest functional disconnectivity of olfactory regions in schizophrenia, which may account for olfactory dysfunction and disrupted integration with other sensory modalities in schizophrenia.
Relational Format
Journal Article
Recommended Citation
Sara Kiparizoska, Toshikazu Ikuta, Disrupted Olfactory Integration in Schizophrenia: Functional Connectivity Study, International Journal of Neuropsychopharmacology, Volume 20, Issue 9, September 2017, Pages 740–746, https://doi.org/10.1093/ijnp/pyx045
DOI
10.1093/ijnp/pyx045
Accessibility Status
Searchable text