![Engineering, School of](../../assets/md5images/ef9dadf3ad0c93fafac78d95efd09d9b.png)
Faculty and Student Publications
Document Type
Article
Publication Date
2-18-2020
Abstract
© Copyright © 2020 Gogineni, Oh, Waters, Kelly, Stone and Hamann. Marine sources have long been known for their potential to produce unique skeletons and various biological activities. Fractionation of the ethanol extracts of an undescribed species of Monanchora Carter, 1883 and a specimen closely comparable to Monanchora pulchra (Lambe, 1894/1895) (Class Demospongiae, Order Poecilosclerida, Family Crambeidae), yielded a known compound, monanchocidin A. Monanchocidin A, a secondary metabolite, showed very modest antibacterial, antifungal, and antiprotozoal activities with IC50 values ranging between 255.75 and 7288.92 μM. Monanchocidin A also exhibited potent selective activity for the melanoma panel in the NCI cancer cell screening panel.
Relational Format
journal article
Recommended Citation
Gogineni, V., Oh, J., Waters, A. L., Kelly, M., Stone, R., & Hamann, M. T. (2020). Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro. Frontiers in Marine Science, 7, 58. https://doi.org/10.3389/fmars.2020.00058
DOI
10.3389/fmars.2020.00058
Accessibility Status
Searchable text