Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro

Authors

Vedanjali Gogineni, University of Mississippi, Research Institute Pharmaceutical Science
Joonseok Oh, University of Mississippi, Research Institute Pharmaceutical Science
Amanda L. Waters, University of Central Oklahoma
Michelle Kelly, National Institute of Water and Atmospheric Research, New Zealand
Robert Stone, NOAA Fisheries Service
Mark T. Hamann, Medical University of South Carolina

Document Type

Article

Publication Date

2-18-2020

Abstract

© Copyright © 2020 Gogineni, Oh, Waters, Kelly, Stone and Hamann. Marine sources have long been known for their potential to produce unique skeletons and various biological activities. Fractionation of the ethanol extracts of an undescribed species of Monanchora Carter, 1883 and a specimen closely comparable to Monanchora pulchra (Lambe, 1894/1895) (Class Demospongiae, Order Poecilosclerida, Family Crambeidae), yielded a known compound, monanchocidin A. Monanchocidin A, a secondary metabolite, showed very modest antibacterial, antifungal, and antiprotozoal activities with IC50 values ranging between 255.75 and 7288.92 μM. Monanchocidin A also exhibited potent selective activity for the melanoma panel in the NCI cancer cell screening panel.

Relational Format

journal article

Recommended Citation

Gogineni, V., Oh, J., Waters, A. L., Kelly, M., Stone, R., & Hamann, M. T. (2020). Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro. Frontiers in Marine Science, 7, 58. https://doi.org/10.3389/fmars.2020.00058

DOI

10.3389/fmars.2020.00058

Accessibility Status

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