Electronic Theses and Dissertations

Date of Award

2015

Document Type

Dissertation

Degree Name

M.S. in Physics

Department

Physics and Astronomy

First Advisor

Kevin S. D. Beach

Second Advisor

Cecille Labuda

Third Advisor

Luca Bombelli

Relational Format

dissertation/thesis

Abstract

Langevin dynamics was used to model the folding and unfolding of simple, hairpin-like biomolecules whose ends are attached to laser-trapped beads, as occurs in optical tweezers experiments. The Langevin process was evolved numerically, using parameters motivated by real experimental systems. Folding trajectories were generated and analyzed to extract the folding rate as a function of the force applied to the beads. The observed rate was compared to the analytical predictions of Kramers' theory. Strong discrepancies were noted. The failure of the Kramers' theory was attributed to the slow dynamical response of the beads, which it does not account for. The results of this work highlight the necessity to include in the modeling the experimental systems that mediate force along the length of the biomolecule.

Included in

Physics Commons

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