Electronic Theses and Dissertations

Date of Award


Document Type


Degree Name

M.S. in Pharmaceutical Science


Pharmaceutics and Drug Delivery

First Advisor

Ikhlas A. Khan

Second Advisor

Robert J. Doerksen

Third Advisor

Samir Ross

Relational Format



Cyanotis. vaga (Lour.) Schult, & Schult. f. (C. vaga) previously called Tradescantia vaga and Cyanotis barbata, is a perennial herb. It is native to Eastern Asia and Tropical Africa. It has been reported that its decoction reduces fever and enhances well-being. Recently, C. vaga has been used widely for its anabolic effects, due to its richness of ecdysteroids. Even though C. vaga is a commedicinal plant (dietary supplement), there are no reports about its effect on the drug metabolizing enzyme Cytochromes P450 to predict its interaction with concomitantly used medications. In this study, eight ecdysteroids were isolated from C. vaga, including two previously reported from C. vaga. The additional six ecdysteroids were reported for the first time from this plant. The extract and isolates were tested for their inhibitory effects on the CYP3A4 enzyme, which is a major CYP isoform involved in the metabolism of commonly-used clinical drugs.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.