Electronic Theses and Dissertations

Date of Award

2019

Document Type

Thesis

Degree Name

M.S. in Pharmaceutical Science

Department

Pharmaceutics and Drug Delivery

First Advisor

Michael Repka

Second Advisor

Eman Ashour

Third Advisor

Walter Chambliss

Relational Format

dissertation/thesis

Abstract

Over the years, three-dimensional (3D) printing has gradually become more common in people's lives. Due to its quick development, it has attracted the attention of researchers in the pharmaceutical industry. The main purpose of this project was to couple fused deposition modelling (FDM) 3D printing with hot melt extrusion (HME) technology to manufacture tablets with different drug release profiles and to solve dose issues related to an individual’s physiological differences and to enhance extended release properties. Ketoprofen was used as the model drug and different properties were added to the polymer to create a formulation suited to HME technology for the production of filaments used for printing. This study also investigated polymer matrices and how 3D printing can affect a drug’s release into the body.

Available for download on Wednesday, September 22, 2021

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