Date of Award
2019
Document Type
Thesis
Degree Name
M.S. in Pharmaceutical Science
Department
Pharmaceutics and Drug Delivery
First Advisor
Michael A. Repka
Second Advisor
Eman Ashour
Third Advisor
Walter Chambliss
Relational Format
dissertation/thesis
Abstract
Over the years, three-dimensional (3D) printing has gradually become more comin people's lives. Due to its quick development, it has attracted the attention of researchers in the pharmaceutical industry. The main purpose of this project was to couple fused deposition modelling (FDM) 3D printing with hot melt extrusion (HME) technology to manufacture tablets with different drug release profiles and to solve dose issues related to an individual’s physiological differences and to enhance extended release properties. Ketoprofen was used as the model drug and different properties were added to the polymer to create a formulation suited to HME technology for the production of filaments used for printing. This study also investigated polymer matrices and how 3D printing can affect a drug’s release into the body.
Recommended Citation
Hu, Zhiqing, "Development of Controlled Release Oral Dosages by Density Gradient Modification Using 3D Printing Technologies" (2019). Electronic Theses and Dissertations. 1623.
https://egrove.olemiss.edu/etd/1623