Electronic Theses and Dissertations

Date of Award


Document Type


Degree Name

M.S. in Pharmaceutical Science

First Advisor

Eman Ashour

Second Advisor

Michael Repka

Third Advisor

Walter Chambliss


University of Mississippi

Relational Format



Hot-melt extrusion and 3D printing are among the recent means of processing techniques adopted in the pharmaceutical industry. These technologies are used as a method of preparing solid dispersions develop complex shapes that are difficult to be obtained using other means of production. In the current research work, many formulations loaded with lidocaine HCl were prepared and extruded using 11mm twin-screw extruder. The extrudate filaments were then fed into a fused deposition modelling (FDM) printer to fabricate mucoadhesive films meant to buccal applications to manage local pain within the oral cavity that requires the intervention with local anesthetics. The printed films drug content was determined using HPLC, films drug content was within the acceptable limits. Furthermore, the drug release was assessed using an in-house method. All test formulations revealed an excellent release profile of the lidocaine HCl, reaching more than 90% within 5-15 min. The films adhesion and mechanical properties were tested using texture analyzer. The results indicated that the films possess an adequate mechanical property to satisfy its intended use. In conclusion, this research work demonstrates that coupling hot-melting extruder to a fused deposition modelling printing is feasible to produce lidocaine-loaded buccal mucoadhesive films intended for local application in the oral cavity.



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