Electronic Theses and Dissertations

Date of Award

1-1-2020

Document Type

Dissertation

Degree Name

Ph.D. in Chemistry

First Advisor

Jared H Delcamp

Second Advisor

Brenda Prager

Third Advisor

Susan Pedigo

School

University of Mississippi

Relational Format

dissertation/thesis

Abstract

The need for NIR fluorescent dyes is widely accepted for imaging and communications applications. Cyanines are a commonly used family of dyes for biological imaging due to their tunability, often rapid synthesis, ease of bioconjugation, intense molar absorptivities and strong NIR emissions. Since the invention of indocyanine green (ICG), many efforts have been made to improve on the design achieving farther red-shifted dyes with larger quantum yields and enhanced Stokes shifts. A series of squaraine, cyanine, and xanthene based dyes using the indolizine heterocycle as a donor in place of the commonly used indoline donor are discussed. The indolizine donor allows for red-shifts farther into the NIR region due to the indolizine being fully conjugated. Additionally, an enhanced Stokes shift is observed to enable high resolution imaging. These series of dyes are discussed with a focus on structure-property relationships concerning the effects on the photophysical properties.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.