Date of Award
1-1-2021
Document Type
Thesis
Degree Name
M.S. in Pharmaceutical Science
Department
Pharmaceutics and Drug Delivery
First Advisor
Dr. Michael A. Repka
Second Advisor
S. Narasimha Murthy
Third Advisor
Dr. Mahavir B. Chougule
Relational Format
dissertation/thesis
Abstract
The main objective of the current research is to investigate the effect of shapes (heart and round shape tablets) and infill densities (50% and 100%) on drug release profiles of tablets prepared by hot melt extrusion (HME) coupled fused deposition modeling (FDM) technique. Two different commercial FDM 3D printers with different filament feeding mechanisms were evaluated for suitability of printing. Drug-loaded filaments of 1.5 mm and 2.5 mm diameters were extruded using Process 11 mm HME, using atorvastatin as a model drug and Kollicoat® IR, Kollidon® VA64, Kollidon®12PF, and Kolliphor® P407 as hydrophilic polymers. Filaments of Kollicoat® IR in combination with Kollidon® VA64 or Kollidon®12PF has resulted in successful printing of dosage forms. Conversion of the drug to amorphous form and no interactions between formulation ingredients is confirmed by differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR). Infill densities greatly influenced drug release profiles over tablet shape. Drug release profiles of tablets are preserved even after storage at accelerated conditions (40±2? and 75±5 %RH) for three month. Tablets of FDM 3D printing have improved dissolution rates compared to conventional tablets manufactured by direct compression technique. Thus FDM 3D printing coupled with HME provides an opportunity for an alternative continuous manufacturing process for developing dosage forms with distinct shapes with an additional benefit of modifying release profiles.
Recommended Citation
MANDATI, PREETHI, "Hot-Melt Extrusion Based Fused Deposition Modeling 3D Printing of Atorvastatin Calcium Tablets: Impact of Shape and Infill Density on Printability and Performance" (2021). Electronic Theses and Dissertations. 2027.
https://egrove.olemiss.edu/etd/2027