Electronic Theses and Dissertations

Date of Award


Document Type


Degree Name

M.S. in Pharmaceutical Science

First Advisor

Eman A. Ashour

Second Advisor

Dr. Walter Chambliss

Third Advisor

Michael A. Repka


University of Mississippi

Relational Format



CBD has been shown to have a wide range of therapeutic effects for epilepsy, which is approved by the FDA, and it has also been studied for its anti-inflammatory, analgesic, and anxiolytic properties. CBD-loaded oral films are a novel drug delivery system designed to improve the therapeutic potential of cannabidiol (CBD), a non-psychoactive cannabinoid derived from the cannabis plant. In this study, CBD-loaded oral films were developed using a combination of anti-solvent precipitation and solvent-casting techniques. These oral films were designed to be thin, flexible, and rapidly disintegrating films. Different grades of hydroxypropyl methylcellulose were used as a film former. Fourier-transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) were used to evaluate the CBD/excipients compatibility and the CBD physical state. The results showed that the CBD-loaded oral films had short disintegration times, good folding endurance, and adequate tensile strength. The dissolution profiles indicated a rapid release of CBD, with more than 85% of the drug released within 15 minutes. The development of CBD-loaded oral film offers several advantages over traditional dosage forms, such as improved patient compliance.

Available for download on Saturday, September 13, 2025