Date of Award
M.S. in Pharmaceutical Science
Michael A. Repka
Dr. Walter Chambliss
University of Mississippi
The objective of the present study was to prepare an improved solubility, and stability. Hot-melt extrusion technology was used to prepare the filaments of insoluble model drug Fenofibrate (FBR). Eudragit® E PO® was used as a immediate release, moisture content control polymer for the formulation. Soluplus was used as a solubility enhancement polymer. Differential scanning calorimetry (DSC) and Fourier-Transform Infrared Spectroscopy (FTIR) confirmed that the binary mixtures were miscible under the employed extrusion temperatures. The binary mixtures (10% FBR /Eudragit® E PO and Soluplus) were blended and extruded with a 6-mm mini extruder and were milled by using a mortar and pestle. In vitro release studies showed that drug release was maximum at 20 min in simulated SLS media. The comparative studies were done in other media like water to assess the enhanced solubility. The results showed a sharp increase in solubility of the drug and the formulation. Thus, it was concluded that the immediate release capsules with Soluplus and Eudragit® E PO had excellent suitability and fulfilled the aim of solubility enhancement and moisture content control.
Dubey, Shrishti, "Formulation and In-Vitro Evaluation of Fenofibrate Capsules Using Hot Melt Extrusion Technology" (2023). Electronic Theses and Dissertations. 2495.
Available for download on Friday, September 13, 2024