Development of poloxamer gel formulations via hot-melt extrusion technology.

Authors

• Nicole Mendonsa, University of Mississippi
• S. Narasimha Murthy, University of Mississippi
• Seyed Meysam Hashemnejad, Mississippi State University
• Santanu Kundu, Mississippi State University
• Feng Zhang, University of Texas at Austin
• Michael A. Repka, University of Mississippi

Department

Pharmacy

Document Type

Article

DOI

10.1016/j.ijpharm.2017.12.008

Publication Date

2-15-2018

Abstract

Poloxamer gels are conventionally prepared by the "hot" or the "cold" process. But these techniques have some disadvantages such as high energy consumption, requires expensive equipment and often have scale up issues. Therefore, the objective of this work was to develop poloxamer gels by hot-melt extrusion technology. The model drug selected was ketoprofen. The formulations developed were 30% and 40% poloxamer gels. Of these formulations, the 30% poloxamer gels were selected as ideal gels. DSC and XRD studies showed an amorphous nature of the drug after extrusion. It was observed from the permeation studies that with increasing poloxamer concentration, a decrease in drug permeation was obtained. Other studies conducted for the formulations included in-vitro release studies, texture analysis, rheological studies and pH measurements. In conclusion, the hot-melt extrusion technology could be successfully employed to develop poloxamer gels by overcoming the drawbacks associated with the conventional techniques.

Relational Format

journal article

Recommended Citation

Mendonsa, N. S., Murthy, S. N., Hashemnejad, S. M., Kundu, S., Zhang, F., & Repka, M. A. (2018). Development of poloxamer gel formulations via hot-melt extrusion technology. International Journal of Pharmaceutics, 537(1-2), 122–131. https://doi.org/10.1016/j.ijpharm.2017.12.008

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