Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells.

Authors

• Bhavisha Bakrania, University of Mississippi Medical Center
• Frank T. Spradley, University of Mississippi Medical Center
• Simon C. Satchell, University of Bristol
• David E. Stec, University of Mississippi Medical Center
• John M. Rimoldi, University of Mississippi
• Rama S. Gadepalli, University of Mississippi
• Joey P. Granger, University of Mississippi Medical Center

Department

Pharmacy

Document Type

Article

DOI

10.1152/ajpregu.00370.2017

Publication Date

3-1-2018

Abstract

Preeclampsia is a pregnancy-specific disorder of maternal hypertension and reduced renal hemodynamics linked to reduced endothelial function. Placental ischemia is thought to be the culprit of this disease, as it causes the release of factors like tumor necrosis factor (TNF)-α that induce vascular endothelin-1 (ET-1) production. Interestingly, placental ischemia-induced hypertension in rats [reduced uterine perfusion pressure (RUPP) model] is abolished by ET

Relational Format

journal article

Recommended Citation

Bakrania, B. A., Spradley, F. T., Satchell, S. C., Stec, D. E., Rimoldi, J. M., Gadepalli, R. S. V., & Granger, J. P. (2018). Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 314(3), R427–R432. https://doi.org/10.1152/ajpregu.00370.2017

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