Honors Theses
Date of Award
Spring 4-16-2021
Document Type
Undergraduate Thesis
Department
Chemistry and Biochemistry
First Advisor
Hoang V. Le
Second Advisor
David Colby
Third Advisor
Pier Paolo Claudio
Relational Format
Dissertation/Thesis
Abstract
Depression has become the fourth leading case for mortality and morbidity in the world. It is a leading cause of disability worldwide and is a major contributor to the overall global burden of disease. Current treatments of depression are inadequate, and the progress in understanding the neurobiology of depression is slow. The first generation antidepressants like monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs) have shown to possess a lot of side effects. Hydrazide-based monoamine oxidase inhibitors are known to result in acute hypertensive crises and hepatotoxicity, as well as to interact with many foods and biogenic amine drugs. Tricyclic antidepressants are known to associate with emotional blunting, confusion, hypersensitivity, hypotension, and sometimes irregular heart rhythms. Research efforts to discover other novel heterocycles that possess antidepressant activity have been intensified recently. One of such discoveries is pyrazole compounds, and their antidepressant activity has been shown to be very promising. Green chemistry was taken into consideration while selecting the bases, catalysts, and solvent mediums for the reactions. The current synthetic methods to access highly functional pyrazoles and the diversity of the chemical starting materials to synthesize pyrazoles are limited. Therefore, this study was aimed at developing a method to synthesize functional pyrazoles by using greener starting materials like dibromoalkene and hydrazides.
Recommended Citation
Trivedi, Riya, "Studies on synthesis of pyrazole from dibromo and hydrazine compounds." (2021). Honors Theses. 1789.
https://egrove.olemiss.edu/hon_thesis/1789
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