Honors Theses
Date of Award
Spring 4-19-2021
Document Type
Undergraduate Thesis
Department
Chemistry and Biochemistry
First Advisor
Saumen Chakraborty
Second Advisor
Susan Pedigo
Third Advisor
Eden Tanner
Relational Format
Dissertation/Thesis
Abstract
Alternative energy is more imperative than ever as we continue to exhaust nonrenewable resources. There is promise in artificial hydrogenases that produce hydrogen gas which can be an alternate source of clean, sustainable renewable energy. Moreover, artificial metalloenzymes were designed for solar H2 production using de novo designed metallopeptides. A computer-guided design approach was used to conceive the peptides. These peptides are 30 amino acids long and are designed to self-assemble into tetrameric structures. There are suitably positioned cysteine residues that bind the metal Co and form metallic clusters within these artificial proteins. The Co-metallopeptides were then characterized by employing spectroscopic techniques. They were found to have varying binding activity and optimal photocatalytic activity with 2 equivalents of Cobalt at pH 5 out of pH’s 4, 5, and 6.3.
Recommended Citation
Le, Thuy Hien, "Artificial De Novo Tetramer Hydrogenase Mimic, Co-Metallopeptide Titration, and Photocatalysis" (2021). Honors Theses. 1923.
https://egrove.olemiss.edu/hon_thesis/1923
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