Date of Award
Communication Sciences and Disorders
Background: This thesis was conducted in order to investigate possible connections between functional connectivity of the hippocampus in individuals who have Parkinson’s disease.
Methods: The MRI images, the clinical data, and the demographic data of 93 individuals with PD and 18 individuals without PD were obtained from the Parkinson's Progression Markers Initiative. Resting-state fMRI data from a group of PD patients was compared to a control group of non-PD patients by using previously published methods with FMRIB Software Library (FSL) as well as Analysis of Functional Neuroimages (AFNI).
Results: Compared to the control (non-PD) group, results bilaterally showed lesser connectivity between the paracingulate gyrus (PCG) and hippocampi in the PD group.
Conclusions: Results suggest a decline of dopaminergic innervation decreases synchrony of the hippocampi and paracingulate gyri (PCG). It is inferred that PD patients who also experience dementia may have a more severe loss of connectivity because of the underlying dopaminergic deficits that cause the onset of dementia.
Llewelyn, Landis, "Hippocampal Connectivity in Parkinson's Disease" (2021). Honors Theses. 1925.
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