Honors Theses
Date of Award
Spring 5-1-2021
Document Type
Undergraduate Thesis
Department
Communication Sciences and Disorders
First Advisor
Tossi Ikuta
Relational Format
Dissertation/Thesis
Abstract
Background: This thesis was conducted in order to investigate possible connections between functional connectivity of the hippocampus in individuals who have Parkinson’s disease.
Methods: The MRI images, the clinical data, and the demographic data of 93 individuals with PD and 18 individuals without PD were obtained from the Parkinson's Progression Markers Initiative. Resting-state fMRI data from a group of PD patients was compared to a control group of non-PD patients by using previously published methods with FMRIB Software Library (FSL) as well as Analysis of Functional Neuroimages (AFNI).
Results: Compared to the control (non-PD) group, results bilaterally showed lesser connectivity between the paracingulate gyrus (PCG) and hippocampi in the PD group.
Conclusions: Results suggest a decline of dopaminergic innervation decreases synchrony of the hippocampi and paracingulate gyri (PCG). It is inferred that PD patients who also experience dementia may have a more severe loss of connectivity because of the underlying dopaminergic deficits that cause the onset of dementia.
Recommended Citation
Llewelyn, Landis, "Hippocampal Connectivity in Parkinson's Disease" (2021). Honors Theses. 1925.
https://egrove.olemiss.edu/hon_thesis/1925
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