Honors Theses
Date of Award
1-1-2010
Document Type
Undergraduate Thesis
First Advisor
Karen Sabol
Relational Format
Dissertation/Thesis
Abstract
Methamphetamine (METH) induces hyperthermia or hypothermia depending on the ambient temperature. The β1 receptor is involved in body temperature control via brown adipose tissue (BAT) thermogenesis. Our objective was to determine the effect of selective β1 antagonist, metoprolol (METO), on METH-induced changes in body temperature in varying ambient conditions. Rats received pretreatment injections of saline, 5.0 mg/kg METO, 10.0 mg/kg METO, or 15.0 mg/kg METO 30 minutes prior to receiving cither saline or 5.0 mg/kg METH injection. Body temperature was measured telemetrically at either 18°C, 24°C, or 30°C ambient temperatures. 10.0 mg/kg METO attenuated METH-induced hyperthermia at 60 minutes in the 24°C ambient temperature. All METO pretreatments attenuated METH-induced hyperthermia in the 30°C ambient temperature. All METO pretreatments enhanced METH-induced hypothermia at 60 minutes in the 18°C ambient temperature. An increase in body temperature was seen with all METH treatments in all ambient temperatures at 180 minutes. What can be concluded from our study is that the β1 antagonist, metoprolol, had a significant reduction in METH-induced body temperature in warm, neutral, and cold ambient temperatures that appears to be linked to the β1 role in BAT thermogenesis.
Recommended Citation
Harrell, Ricki Lee, "The Effects of the Beta1 Receptor Antagonist, Metoprolol, on Methamphetamine-Induced Changes in Body Temperature in Varying Ambient Temperatures" (2010). Honors Theses. 2764.
https://egrove.olemiss.edu/hon_thesis/2764
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