Honors Theses

Date of Award

Spring 5-14-2023

Document Type

Undergraduate Thesis

Department

Chemistry and Biochemistry

First Advisor

Toshikazu Ikuta

Second Advisor

Laura Dixon

Third Advisor

Todd Smitherman

Relational Format

dissertation/thesis

Abstract

AVP-923, commonly known as Nuedexta or Zenvia, is a drug that has recently been suggested as a potential treatment for Pseudobulbar Affect in patients affected by different neurological disorders and injuries. Studies have been done to examine the effectiveness of AVP-923 on PBA, but the results of these studies don’t seem to be comparable. The goal of this meta-analysis is to assess the efficacy and safety of AVP-923. 781 individuals from six trials were included in the analysis. The analysis's findings revealed that AVP-923 considerably lowered the Center for Neurological Study Lability Scale (CNS-LS) scores and the frequency and severity of PBA episodes in these individuals. With mild to moderate side effects observed, the medication was also found to be safe and well-tolerated. The findings of this meta-analysis provide important clinical implications for the management of PBA symptoms in this patient population.

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Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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