The Effects of Cannabidiol Mono-Valinate Mono-Hemisuccinate on Spontaneous Withdrawal in a Murine Model of Opioid Dependence

Author

• Adya Praveen, University of MississippiFollow

Date of Award

Spring 5-9-2026

Document Type

Undergraduate Thesis

Department

Psychology

First Advisor

Kenneth Sufka

Second Advisor

Hannah Harris

Third Advisor

Alberto Del Arco

Relational Format

Dissertation/Thesis

Abstract

Purpose: This study sought to determine whether the cannabidiol analog, cannabidiol mono-valinate mono-hemisuccinate (CBD-VHS), could mitigate symptoms of opioid withdrawal in oxycodone-dependent mice.

Experimental Approach: To establish opioid dependence, mice received either saline or oxycodone in a dose-escalation fashion (10, 20, 40, 60 mg/kg) for nine consecutive days. In the spontaneous withdrawal stage occurring 24 hours after the last oxycodone dosing, animals received either vehicle or CBD-VHS (4, 8, or 12 mg/kg) one hour prior to testing. Withdrawal symptoms recorded were paw tremors, jumps, grooming frequency, and fecal boli counts.

Keywords: opioid use disorder; cannabidiol analog; withdrawal; relapse

Recommended Citation

Praveen, Adya, "The Effects of Cannabidiol Mono-Valinate Mono-Hemisuccinate on Spontaneous Withdrawal in a Murine Model of Opioid Dependence" (2026). Honors Theses. 3404.
https://egrove.olemiss.edu/hon_thesis/3404

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