O-GLCNAC Post Translational Modification of Hypoxia-Inducible Factor (HIF) Proteins

Author

Hailey Elisabeth Grisham, University of Mississippi. Sally McDonnell Barksdale Honors College

Date of Award

2018

Document Type

Undergraduate Thesis

Department

Chemistry and Biochemistry

First Advisor

Yu-Dong Zhou

Second Advisor

Dale Nagle

Relational Format

Dissertation/Thesis

Abstract

O-linked β-N-acetylglucosamine (O-GlcNAc) post-translational modification (O- GlcNAcylation), plays a vital role in many metabolic pathways, including those of numerous diseases. New research methods and basic functional roles of O-GlcNAc post- translational modification on metabolism, human health, and cancer are quickly developing, but a vast amount of research remains on the specificity of this pathway towards specific proteins. In this study, T47D breast cancer cells were used as an in vitro model to investigate the effects of O-GlcNAc modification on hypoxia-inducible factor (HIF) proteins.

Recommended Citation

Grisham, Hailey Elisabeth, "O-GLCNAC Post Translational Modification of Hypoxia-Inducible Factor (HIF) Proteins" (2018). Honors Theses. 360.
https://egrove.olemiss.edu/hon_thesis/360

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